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KMID : 1234520110060010048
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Korean Journal of Urogenital Tract Infection Inflammation
2011 Volume.6 No. 1 p.48 ~ p.53
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Changes of Interleukin-1β in the Prostate Secretions of Chronic Nonbacterial Prostatitis Patients
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Yoon Ha-Na
Lee Dong-Hyun
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Abstract
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Purpose: To measure changes in prostate cytokine secretion in chronic non-bacterial prostatitis (NBP) patients and examine the clinical usefulness of these changes in differentiating the pathophysiologic mechanism of NBP and subsequent selection of treatment modalities.
Materials and Methods: Sixty male patients were diagnosed with chronic NBP, and a control group comprised of 30 male patients without clinical evidence of NBP were enrolled in this study. Prostate secretion (centrifuged VB3) was analyzed at the initialdiagnosis and 8 weeks after treatment initiation. Patients who showed more than 10 white blood cells (WBCs)/high power field (HPF) 8 weeks after treatment initiation were categorized into group A. Group B patients had less than 3 WBCs/HPF. Group B was further subclassified into two groups according to presence of symptoms after treatment: Bp (symptom-persisted) and Br (symptom-resolved). IL-1β, C3, C4, IgG were measured and the results were analyzed.
Results: There were significant differences in the IL-1β level in the control group compared to group A, Bp and Br (p<0.05). C3, C4, IgG showed higher levels in groups A and B than in the control group, albeit without statistical significance (p>0.05).
Conclusions: Elevated IL-1β in group Bp suggests that chronic NBP patients who did not respond to treatment could exhibitclinical manifestations of autoimmune reactions rather than infection of external origin. We suggest that a more advanced diagnostic technique using cytokine at the initial stage of disease manifestation tohelp clinicians avoid unnecessary antibiotic treatment and manage the condition more effectively.
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KEYWORD
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Autoimmunity, Cytokines, Prostatitis
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